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4 Mechanisms mediating neutrophil activation and NETs formation in ECMO An increasing number of studies have shown that activation of the inflammatory response plays an important role in the development of acute organ injury, and very important pathophysiological mechanisms are likely secondary to cross-cascade activation of the complement, contact, and coagulation systems, as well as the mechanical forces of the circuitry, which lead to neutrophil activation and the production of NETs ( Figure 2 )

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reported outcomes are more plausibly indirect via recovery, routine adherence, and activity changes

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